Hanaa Hariri (hg7223)

University information

Title: Assistant Professor

Unit: Biological Sciences

Department: College of Liberal Arts & Science

Contact information

313-993-4217

hanaa.hariri@wayne.edu

Department of Biological Sciences

1360 Biological Sciences Building

Detroit, 48202

College of Liberal Arts and Sciences

Department:

Biological Sciences

Title: Assistant Professor

Email: hanaa.hariri@wayne.edu

Office:

Biological Sciences Building Rm: 4107, 5177

Curriculum Vitae: https://people.wayne.edu/profile/hg7223/1578/hariri_cv_hh_22.pdf 232732 1666103584 file

Social Media: https://twitter.com/hanahariri https://linkedin.com/in/hanaa-hariri-16493639/

Research interest(s)/area of expertise:

Inter-organelle contact sites

Lipid trafficking, storage, and utilization

Organization of metabolic networks

Nutrient signaling

Aging and metabolic disorders

Research:

The Hariri research group employs a multi-disciplinary approach combing proteomics, lipidomics, and high-resolution imaging, with metabolic analysis as well as classical biochemistry and genetics to study the regulation and spatial organization of metabolic pathways using yeast and human cell lines. We are particularly interested in fatty acid trafficking and metabolism at organelle contact sites. We are also interested in elucidating the principles that govern the crosstalk between metabolic networks.

Education – Degrees, Licenses, Certifications: B.S., Biological Sciences, Lebanese University, Hadath, Lebanon (2007) M.Sc., Cell and Molecular Biology, American University of Beirut, Beirut, Lebanon (2009) Ph.D., Molecular Biophysics, Florida State University, Tallahassee FL (2015) Postdoctoral fellow, Cellular Metabolism, University of Texas Southwestern Medical Center, Dallas TX (2020)

Selected publications:

2022:

Vladimir Girik, Suihan Feng, Hanaa Hariri, W Mike Henne, Howard Riezman (2022). Vacuole-specific lipid release for tracking intracellular lipid metabolism and transport in Saccharomyces cerevisiae. ACS Chem. Biol. 2022, 17, 6, 1485–1494

Hanaa Hariri, Mike Henne (2022). Filling in the gaps: SNX-RGS proteins as multi-organelle tethers. Journal of Cell Biology. DOI: 10.1083/jcb.202203061

Blessy Paul, Saroja Weeratunga, Vikas A. Tillu, Hanaa Hariri, W. Mike Henne and Brett M. Collins (2022). Structural Predictions of the SNX-RGS Proteins Suggest They Belong to a New Class of Lipid Transfer Proteins. Front. Cell Dev. Biol., https://doi.org/10.3389/fcell.2022.826688

2021:

Mike F. Renne, Hanaa Hariri* (2021). Fatty Acid Channeling, Trafficking, and Metabolism at Lipid Droplet Contact Sites. Frontiers in Cell Dev. Biol. doi: 10.3389/fcell.2021.726261. *Corresponding author.

Lluc Mosteiro, Hanaa Hariri, Jelle van den Ameele (2021). Metabolic decisions in development and disease. Development. Meeting Review. Vol. 148 Issue 11.

Sean Rogers, Hanaa Hariri, Long Gui, N. Ezgi Wood, Natalie Speer, Daniela Nicastro, W. Mike Henne (2021). Glucose restriction drives spatial reorganization of mevalonate metabolism. Elife. 10:e62591 DOI: 10.7554/eLife.62591.

2020:

Hanaa Hariri (2020). Topography and Functions of Membrane Contact Sites. Encyclopedia of Biological Chemistry 3rd Edition.

N Ezgi Wood, Piya Kositangool, Hanaa Hariri, Ashley Marchand, Mike Henne (2020). Nutrient signaling, stress response, and interorganelle communication are non-canonical determinants of cell fate. Cell Reports. Vol 33, Issue 9.

Sanchari Datta, Jade Bowerman, Hanaa Hariri, Rupali Ugrankar, KaitlynM. Eckert, Chase Corley, Gonçalo Vale, Jeffrey G. McDonald, Mike Henne (2020). Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease. Proceedings of the National Academy of Sciences 117 (52) 33282-33294.

Mike Henne, Joel Goodman, Hanaa Hariri* (2020). Spatial compartmentalization of lipid droplet biogenesis. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1865, 158499. *Corresponding author.

2019:

Rupali Ugrankar, Jade Bowerman, Hanaa Hariri, Sanchari Datta, Sonia Gonzalez, Joseph Gonzalez, and W. Mike Henne (2019). Drosophila Snazarus regulates a lipid droplet sub-population at plasma membrane-droplet contacts in fat body adipocytes. Developmental Cell. 50: 557–572.

Hanaa Hariri, Natalie Speer, Jade Bowerman, Sanchari Datta, Sean Rogers, Ryan Feathers, Rupali Ugrankar, W. Mike Henne (2019). Mdm1 maintains endoplasmic reticulum homeostasis by spatially regulating fatty acid processing and lipid droplet biogenesis. Journal of Cell Biology. 218:1319-1334.

Sanchari Datta, Yang Liu, Hanaa Hariri, W. Mike Henne (2019). Cerebellar ataxia disease-associated Snx14 promotes lipid droplet growth at ER-droplet contacts. Journal of Cell Biology. 218:1335-1351.

2018:

Hanaa Hariri, Sean Rogers, Rupali Ugrankar, Yang Lydia Liu, J. Ryan Feathers, W. Mike Henne (2018). Lipid droplet biogenesis is spatially coordinated at yeast ER-lysosome contact sites in response to nutritional stress. EMBO Reports. 19: 57–72.

Dale Bryant, Yang Liu, Sanchari Datta, Hanaa Hariri, Glenn Anderson, Emma Peskett, Charalambos Demetriou, Marian Seda, Dagan Jenkins, Sergio Sousa, Peter Clayton, Maria Bitner-Glindzicz, Gudrun Moore, Mike Henne, Philip Stanier (2018). SNX14 mutations affect cholesterol metabolism at the endoplasmic reticulum in SCAR20. Human Molecular Genetics. 27:1927–1940.

Hanaa Hariri, Rupali Ugrankar, Yang Liu, and W. Mike Henne (2018). Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution. Communicative and Integrative Biology. Review. 9(3):e1156278

Click here to see the complete list of publications

Other writings and interviews:

Meet a Women in STEM: Hanaa Hariri. WSU GEARS project interview (2022)

A Portable Career Coach. The POSTDOCket (2018)

A Candid and Humorous Look at Life at the Tenure Track. The POSTDOCket (2017)

Do You Have to be a Man to be a Woman in Science? ASCB Post (2015)

Women in Science: The Untold Downside to Achievement. ASCB Post (2014)

Citation index:

Google Scholar Link