Pei-Chung Lee (hb8242)
University information
Contact information
College of Liberal Arts and Sciences
4137 Biological Sciences
Host-pathogen interactions
Innate immunity
Microbiology/bateriology
Post-translational modifications
Our laboratory is interested in infection strategies used by bacterial pathogens to cause diseases. We use multidisciplinary approaches to dissect the moelcular interactions between the emerging pathogen, Legionella pneumophila, and their host cells.
Our team welcomes motivated students from all backgrounds (graduate and undergraduate students) to join the lab and explore exciting areas of host-pathogen interactions with us.
Currently accepting graduate student(s) for: Fall 2024
When contacting, please let us know how your research interest aligns with our reasech focus and your learning goals in our lab.
University Research Grant 2020-21, Wayne State University (Role: PI)
- Brendyn M. St. Louis, Sydney M. Quagliato, Yu-Ting Su, Gregory Dyson, Pei-Chung Lee#. (2024) The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes. mBio (in press, #corresponding author)
- Brendyn M. St. Louis, Sydney M. Quagliato, Pei-Chung Lee#. (2023) Bacterial effector kinases and strategies to identify their target host substrates. Frontiers in Microbiology-Infectious Agents and Disease (#corresponding author)
- Pei-Chung Lee, Ksenia Beyrakhova, Caishuang Xu, Michal T. Boniecki, Mitchell H. Lee, Chisom J. Onu, Andrey M. Grishin, Matthias P. Machner, Miroslaw Cygler. (2020) Structural insight into a bacterial kinase-host activator complex that exploits the mammalian Hippo pathway. Proceedings of the National Academy of Sciences of the USA
- Pei-Chung Lee and Matthias P. Machner. (2018) The Legionella effector kinase LegK7 hijacks the host Hippo pathway to promote infection. Cell Host & Microbe
- Pei-Chung Lee and Arne Rietsch. (2015) Fueling type III secretion. Trends in Microbiology
- Pei-Chung Lee, Stephanie Zmina, Charles M. Stopford, Jonida Toska, Arne Rietsch. (2014) Control of type III secretion activity and substrate specificity by the cytoplasmic regulatory protein PcrG. Proceedings of the National Academy of Sciences of the USA
