Berhane Seyoum M.D., MPH, Professor (Clinician-Educator) (ar5478)

I have been a faculty member since 2007. My main area of interest is diabetes and my research focuses on insulin resistance. Currently, I have two NIH-funded collaborative major research projects. We are one of the few centers in the country that can conduct insulin clamp studies and perform fat as well as muscle biopsies. Interest fellows are welcome to join my study team. We will give you all the necessary training to reach your research goals. Our program offers a rich training experience with complex diabetes patients. I am confident that after completing our program you will have gained the expertise needed to expertly manage complex diabetes patients using the most up-to-date diagnostic and therapeutic strategies.
 

University Health Center
4201 St. Antoine St. Suit 4H
Detroit, MI 48201

• M.D., Addis Ababa University, Medical Faculty, Addis Ababa, Ethiopia 1980 - 1987
• Specialty degree, Residency in internal medicine Addis Ababa University, Medical Faculty, Addis Ababa, Ethiopia 1989 - 1992
• Specialty degree, Residency in internal medicine, New York Methodist Hospital. Brooklyn, New York 2001 - 2003
• Fellowship in Endocrinology, Division of Endocrinology, Wayne State University, Detroit, MI 2003 - 2006
• M.P.H., Community Medicine, Wayne State University, Detroit, MI 

Awards & Honors:

• Third world Medical Foundation awards for Excellence in Research. Received on May 22, 1993.
• Ethiopian Science and Technology Commission research grant, for a research on Type 2 diabetic patients with secondary failure to Sulfonylurias, awarded in 1995.
• Eli Lilly foot amputation prevention program grant, for a research on Identification of high risk foot in diabetic patients in developing countries, awarded in 1997.
• Ethiopian Science and Technology Commission research grant, for a research on the study of microorganism flora in diabetic patients with periodental diseases, awarded in 1997.
• Tigray Development Association research grant award, for the study of prevalence of gestational diabetes in rural pregnant mothers in northern Ethiopia.
• International Diabetes Federation Educational grant award, for clinical research on hypertension and Diabetes mellitus, awarded in 1999.
• Precetorship award from Endocrine Foundation for training in advanced lipidology at Duke University, May 1-15, 2005

Professional Societies:

1. American Diabetes Association.
2. The Endocrine Society.
3. International Diabetes Federation.
4. Pan African Diabetes Study Group.
5. National Lipid Association.
6. American Association of Clinical Endocrinologists

Clinically I am very much interested in managing pumps and reading continuous glucose monitoring devices. At this time, I have over 600 insulin pump patients. During your training, you will learn how to manage patients with both tubed and tubeless insulin pumps.

1.              Hodes RM, Seyoum B. The pattern of tuberculosis in Addis Ababa, Ethiopia. East African Medical Journal 1989; 66:812-18. PMID: 2612412 

2.              Seyoum B, Amaro JC. Bronchial Asthma in Jima: a prospective analysis of 204 patients. Ethiopian Medical Journal 1992; 30:225-32. PMID: 1459122  

3.              Seyoum B, Abdulkadir J, Kumssa A. One day at the diabetic clinic; diminishing time supply for complex health care needs and a growing patient load. International Diabetes Digest 1996; 7:35-38.

4.              Seyoum B, Abdulkadir J. Systemic inspection of insulin injection sites for local complications related to incorrect injection technique. Tropical Doctor 1996; 26:159-61. PMID: 8937229

5.              Wolday D, Seyoum B. Pleural empyema due to Salmonella paratyphi in a patient with AIDS. Tropical Medicine and International Health 1997; 2:1140-42. PMID: 9438469

6.              Seyoum B. Impotence in Ethiopian diabetic men. East African Medical Journal 1998; 75:208-10. PMID: 9745835

7.              Seyoum B, Gebregziabher F, Abdulkadir J, Alemayehu B. The occurrence of Diabetic Ketoacidosis in Tikur Anbessa Hospital, Ethiopia. International Diabetes Digest 1998; 9:38-39.

8.              Seyoum B, Abdulkadir J, Feleke Y, Worku Y. Insulin storage by diabetic patients in Ethiopia. International Diabetes Digest 1998; 9:43-44.

9.              Seyoum B, Abdulkadir J. Randomized clinical trial of insulin alone or insulin in-combination with sulphonylureas in the treatment of NIDDM patients with secondary failure to sulphonylureas. Ethiopian Medical Journal 1998; 7:11-17.

10.           Seyoum B, Abdulkadir J, Gebregziabher F, Alemayehu B. Analysis of        diabetic patients admitted to Tikur Anbessa hospital over 8 years. Ethiopian Journal for Health Development 1999; 13:9-13.

11.           Seyoum B, Abdulkadir J, Berhanu P, Feleke Y, Worku Y, Ayana G. Profile of coronary risk factors in Ethiopian diabetic patients. East African Medical Journal 1999;76:105-7. PMID: 10442133

12.           Seyoum B, Kiros K, Haileselasie T, Leole A. Prevalence of gestational   diabetes mellitus in rural pregnant mothers in northern Ethiopia. Diabetes Research and Clinical Practice 1999;46:247-51. PMID: 10624791

13.           Seyoum B, Mengistu Z, Berhanu P, Abdulkadir J, Feleke Y, Worku Y, Ayana G. Retinopathy in patients of Tikur Anbessa Hospital diabetic clinic. Ethiopian Medical journal 2001;39:123-31. PMID: 11501289

14.           Teshome T, Seyoum B. Graves’ thyroid Ophthalmopathy in Ethiopian patients. Ethiopian Medical Journal 2001;39:1-8. PMID: 11338463

15.           Seyoum B, Abdulkadir J, Berhanu P, Feleke Y, Mengistu Z, Worku Y, Ayana G. Analysis of serum lipids and lipoproteins in Ethiopian diabetic patients. Ethiopian Medical journal 2003;41:1-8. PMID: 12764995

16.           Seyoum B, Berhanu P. Profile of diabetic ketoacidosis in a predominantly African American urban patient population. Endo trends 2006;5:6.

17.           Siraj ES, Seyoum B, Saenz C, Abdulkadir A. Lipid and lipoprotein profiles in Ethiopian patients with diabetes mellitus. Metabolism, 2006;55:706-10. PMID: 16713427

18.           Seyoum B, Estacio RO, Berhanu P, Shrier RW. Exercise capacity is a predictor of cardiovascular events in patients with type 2 diabetes mellitus. Journal of diabetes and vascular research, 2006;3:197-201. PMID: 17160916

19.           Seyoum B, Berhanu P. Profile of diabetic ketoacidosis in a predominantly African American urban patient population. Ethnicity and disease, 2007;17:234-237. PMID: 17682351

20.           Mamdani N, Repp AL, Seyoum B, Berhanu P. Idiopathic hypoparathyroidism presenting with severe hypocalcemia and asymptomatic basal ganglia calcification followed by acute intracerebral bleed. Endocrine Practice, 2007;13:487-92. PMID: 17872351

21.           Seyoum B, Siraj ES, Saenz C , Abdulkadir A. Hypomagnesemia in Ethiopians with Diabetes Mellitus. Ethnicity and Disease Journal, 2008;18:147-51. PMID: 18507265

22.          Seyoum B, Siraj ES, Saenz C, Abdulkadir J. Low levels of magnesium place diabetics at increased risk. Ethn Dis. 2008;18:238. PMID: 18509935

23.           Seyoum B, Mebrahtu G, Usman A, Mufunda J, Tewolde B, Haile S, Kosia A, Negassi E. Profile of patients with diabetes in Eritrea: results of first phase registry analyses. Acta Diabetologica 2010;47: 23-27. PMID: 19183840

24.           Zambare S, Samantray J, Seyoum B, Abou-Samra AB. Glucose and lipid metabolism in African American patients with type 2 diabetes and chronic hepatitis C viral infection. Endocr Pract. 2011;17:363-368. PMID: 21134881

25.           Seyoum B. Sitagliptin and metformin - novel combination therapy. Expert Opin Pharmacother. 2011;12:6. PMID: 21291346

26.           Seyoum B, Fite A, Abou-Samra AB. Effects of 3T3 adipocytes on interleukin-6 expression and insulin signaling in L6 skeletal muscle cells. Biochemical and Biophysical Research Communications. 2011;410:13-18. PMID: 21640704

27.           Seyoum B, Fite A, Abou-Samra AB. Sitagliptin suppresses active ghrelin in patients with diabetes. J Diabetes Metabolism. 2011;2:157-161.

28.           Araia M, Wood M, Kroll J, Abou-Samra A, Seyoum B. Resolution of Diabetes After Bariatric Surgery Among Predominantly African-American Patients: Race has no Effect in Remission of Diabetes After Bariatric Surgery. Obesity Surgery 2014;24:835-40. PMID: 24442424

29.           Caruso M, Ma D, Msallaty Z, Lewis M, Seyoum B, Al-Janabi W, Diamond M, Abou-Samra AB, Højlund K, Tagett R, Draghici S, Zhang X, Horowitz JF, Yi Z. Increased Interaction with Insulin Receptor Substrate-1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes. Diabetes. 2014;63:1933-47. PMID: 24584551

30.           Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. Scientific Reports 2014;4:5013. PMID: 24852694.  

31.           Fite A, Abou-Samra AB, Seyoum B. Macrophages Inhibit Insulin Signaling in Adipocytes: Role of Inducible Nitric Oxide (NO) Synthase (iNOS) and NO. Canadian Journal of Diabetes 2015; 39:36-43. PMID: 25179174.

32.           Berhane F, Fite A, Daboul N, Al-Janabi A, Msallaty Z, Caruso M, Lewis MK, Yi Z, Diamond MP, Abou-Samra AB, Seyoum B. Plasma Lactate levels increase during hperinsulinemic euglycemic clamp and oral glucose tolerance test.  Journal of diabetes research 2015; Vol 2015, article ID 102054: PMID: 25961050 

33.           Araia A, Roxas R,  Abou-Samra AB, Seyoum B. Prevalence of Diabetes in an Urban Hospital Emergency Room Serving Predominantly Endogenous Population. Journal of the National Medical Association 2015; 107: 11-16. PMID: 27282523

34.           Mishra M, Lillvis J, Seyoum B, Kowluru RA. Peripheral Blood Mitochondrial DNA Damage as a Potential Noninvasive Biomarker of Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2016; 57: 4035-44. PMID: 27494345

35.           Muzik O, Burghardt P, Yi Z, Kumar A, Seyoum B. Successful metformin treatment of insulin resistance is associated with down-regulation of the kynurenine pathway. Biochem Biophys Res Commun. 2017;488:29-32. PMID: 28478038

36.           Holman RR, Bethel MA, Mentz RJ, Thompson VP, Lokhnygina Y, Buse JB, Chan JC, Choi J, Gustavson SM, Iqbal N, Maggioni AP, Marso SP, Öhman P, Pagidipati NJ, Poulter N, Ramachandran A, Zinman B, Hernandez AF; Seyoum B - EXSCEL Study Group. Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes. N Engl J Med. 2017;377:1228-1239. PMID: 28910237

37.           Burghardt KJ, Seyoum B, Mallisho A, Burghardt PR, Kowluru RA, Yi Z. Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies. Prog Neuropsychopharmacol Biol Psychiatry. 2018;83:55-63. PMID:29325867

38.           Burghardt KJ, Seyoum B, Dass S, Sanders E, Mallisho A, Yi Z. Association of Protein Kinase B (AKT) DNA Hypermethylation with Maintenance Atypical Antipsychotic Treatment in Patients with Bipolar Disorder. Pharmacotherapy. 2018;38:428-43. PMID: 29484683

39.           Gupta D, Sarwan Kumar S, Seyoum B. Blister-Packed Levothyroxine Sodium or Bottle-Packed Levothyroxine Sodium. Journal of basic and clinical physiology and pharmacology. 2018;29:309-311.  PMID: 29949511

40.           Gao N, Lee P, Liang Q, Seyoum B, Yu XF. Opposing Effects of IL-1Ra and IL-36Ra on innate immune response to Pseudomonas aeruginosa infection in C57BL/6 Mouse Corneas. Journal of Infections disease 2018 Jul 15;201:688-699. PMID: 29891552

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Research and Professional Experience:

• 1987 - 1989: General practitioner/Assistant lecturer, Jima Institute of Health Sciences, Jima, Ethiopia.
• 1992 - 1999: Assistant Professor of Medicine, Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
• 1996 - 1999: Head of Endocrine/Diabetes Unit, Medicine, Addis Ababa University, Addis Ababa, Ethiopia.
• 1999 - 2001: Research fellow, Internal Medicine, University of Colorado Health Sciences Center, Colorado.
• 2001 - 2003: Intern/Resident, New York Methodist Hospital, Brooklyn, New York.
• 2003 - 2006: Fellow, Davison of Endocrinology, Wayne State University, Detroit, Michigan.
• 2004 - 2007: MPH student in public health at Wayne State University
• 2006 - 2012: Assistant professor of Medicine, Wayne State University, Detroit, Michigan.
• 2010 - present: Medical Chief, Diabetes programs
• 2013 - present:  Associate Professor of Medicine, Wayne State University, Detroit, Michigan
• 2013 - 2020 Interim Chief, Division of Endocrinology, Wayne State University School of Medicine