James G. Granneman (aa4929)

Education:

B.A., Psychology, Southern Illinois University 1976
Ph.D., Biopsychology, University of Massachusetts 1981
Post Doc, Endo/Metabolism, University of Rochester School of Medicine 1981-1982
Post Doc, Neurobiology, University of Pittsburgh 1982-1985

Positions and Honors:

1981-1982 - I nstructor and Fellow in Medicine (Endocrinology and Metabolism), University of Rochester School of Medicine
1982-1985 - Research Associate, Department of Biological Sciences, University of Pittsburgh
1985-1991 - Chief, Laboratory of Biochemical Pharmacology
1986-1991 - Center for Cell Biology, Sinai Research Institute, Assistant Professor of Psychiatry, Wayne State University School of Medicine
1991-1996 - Associate Professor of Psychiatry (Tenured)
1996-date - Wayne State University School of Medicine Professor of Psychiatry and Behavioral Neuroscience, Wayne State University School of Medicine
1998-2001 - Research Fellow, Cell Biology, Parke-Davis/Pfizer Global Research and Development, Ann Arbor
2001-date - Director, Center for Integrative and Metabolic Research Professor of Pathology, Wayne State University School of Medicine

Awards & Honors:

1972-1976 - Illinois State Scholar
1979-1980 - NIMH Predoctoral Trainee, University of Massachusetts
1981-1982 - Postdoctoral Fellow in Diabetes, Endocrine and Metabolic
1981-1982 - Research, (NIADDK) Univ. of Rochester School of Medicine
1983-1985 - National Research Service Award (NINCDS)
1998 - Department Research Excellence Award
2001-Present - Editorial Board, Am. J. Physiology (Endocrinology and Metabolism)
2002 - Editorial Board, J. Experimental Diabetes Research
2002-2006 - Grant Review Panel, American Diabetes Association, NIH Cellular Aspects of Diabetes and Obesity (Ad Hoc)

Ongoing Research:

RA29 (J. Granneman, PI)
American Diabetes Association 7/01/06 - 6/30/09
'Analysis of lipolytic trafficking' The aims of this grant are to 1) characterize the temporal and spatial interactions of Plin-interacting proteins in live model cells adipocytes, focusing on HSL and Abhd5, and 2) to test the hypothesis that Abhd5 modulates the onset and termination of hormone stimulated lipolysis.

Ro1 DK62292 (J. Granneman, PI) 5
/31/03 - 9/30/11 NIH NIDDK
'Analysis of cellular plasticity in white adipose tissue' The project examines the plasticity of cellular phenotypes in white fat during catabolic stimulation by beta 3 receptor agonists.

Ro1 DK066164-01 (Dhurandhar NV, PI; Granneman, Investigator)
9/1/2003 - 8/31/2007 NIH / NIDDK
'Mechanism of Promotion of Adipogenesis by Adenovirus-36' The project examines the mechanisms by which Ad-36 promotes adipogenesis.

Completed:

R21 DK 66505 Granneman, JG (PI)
9/01/03 - 1/31/07 NIH/NIDDK
'Analysis of therapeutic adipose tissue remodeling' This project seeks to develop a transgenic model for inducible genetic manipulation. This model will then be used for lineage tracing in two drug models of adipose tissue remodeling.

MLSC 27, Granneman, JG (PD)
9/01/02 - 8/31/06 Michigan Economic Development Commission
'Michigan Diabetes Research Consortium' This project was a consortium of labs from Univ. Michigan, Michigan State Univ. and Wayne State Univ. The goal of the consortium was to develop and test new models of obesity/diabetes.

RO1 DK46339 Granneman, JG
(PI) 12/01/93 - 6/30/03 NIH/NIDDK
'Analysis of beta1 and beta3 adrenoreceptors' This project examined the differential pharmacological and signaling properties of beta1 and beta3 receptors in adipocytes.

Ro1 MH60854-01 (M. Bannon, PI, Granneman, Co-PI)
12/01/99- 11/30/04 NIMH
'Analysis of striatal-specific RGS9' This project evaluated the subcellular targeting, regulation and signaling properties of RGS9-L, a RGS subtype expressed in dopamine target cells. Responsibilities of Dr.Granneman (Co-PI) included yeast two-hybrid analysis

 Center for Integrative Metabolic and Endocrine Research (CIMER)

Adipose tissue remodeling, molecular mechanisms of lipolysis in fat and muscle, drug target discovery.

Disease/Disorder

Diabetes and obesity.

Species

Mice.

Methods

Confocal microscopy, live cell protein-protein interaction assays, molecular biology, cell biology and high throughput compound screening

Key Collaborators

HP Moore, Ryan Thummel, Mark Cheng, Guangzhao Mao

 PubMed Search (past 5 years).