Hyeong-Reh C. Kim (aa4695)
University information
Contact information
Cancer Biology Program
Professor
9271 Scott Hall
540 E. Canfield Ave.
Detroit, MI 48201
Pathology
The long term objective of Dr. Kim’s research is to unveil the molecular and cellular mechanisms by which proteolytic and growth factor signaling networks contribute to tumor progression. Dr. Kim’s laboratory has investigated platelet-derived growth factor (PDGF) isoform-specific signal transduction pathways and their roles in prostate and breast cancer progression. Recently, Dr. Kim’s laboratory showed that tumor-produced PDGF C and D undergo proteolytic activation by the serine proteases uPA and matriptase and mediate stromal reactions, critical for tumor cell invasion and metastasis. The laboratory of Dr. Kim has also investigated the pleiotropic activity of tissue inhibitor of metalloproteinases (TIMP)-1 during cancer progression. Dr. Kim’s recent study identified the tetraspanin member CD63 as the first TIMP-1 binding cell surface protein, which mediates the integrin β1 survival pathway as well as phenotypic changes resembling an epithelial mesenchymal transition (EMT).
Warner RB, Najy AJ, Jung YS, Fridman R, Kim S, Kim HRC. Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer Therapy. Sci Rep. 2020;10:2099.
Bottrell A, Meng YH, Najy AJ, Hurst N Jr, Kim S, Kim CJ, Kim ES, Moon A, Kim EJ, Park SY, Kim HRC. An oncogenic activity of PDGF-C and its splice variant in human breast cancer. Growth Factors. 2019;37:131-45.
Najy AJ, Dyson G, Jena BP, Lin CY, Kim HR. Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis. Am J Physiol Cell Physiol. 2016;310:C293-304.
Huang W, Kim HR. Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis. J Biol Chem. 2015;290:9162-70.
Huang W, Fridman Y, Bonfil RD, Ustach CV, Conley-LaComb MK, Wiesner C, Saliganan A, Cher ML, Kim HR. A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth. Oncogene. 2012;31:4527-35.
Ustach CV, Huang W, Conley-LaComb MK, Lin CY, Che M, Abrams J, Kim HR. A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer. Cancer Res. 2010;70:9631-40.
Jung KK, Liu XW, Chirco R, Fridman R, Kim HR. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 2006;25:3934-42.
PhD (1989): Northwestern University, Evanston, IL
Post-Doc (1990-1991): Northwestern University Cancer Center, Evanston, IL
Post-Doc (1991-1992): Washington University, St. Louis, MO
CB7210 Fundamentals of Cancer Biology
Department of Pathology
Scott Hall, Room 9271
540 East Canfield Avenue
Detroit, MI 48201
Ph.D. (1989): Northwestern University, Evanston, IL, USA
Postdoctoral Fellowship
1990-1991, Northwestern University Cancer Center, Chicago, IL, USA
1991-1992, Washington University, St. Louis, MO, USA
Warner RB, Najy AJ, Jung YS, Fridman R, Kim S, Kim HRC. Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer Therapy. Sci Rep. 2020 Feb 7;10(1):2099. PMID: 32034211
Bottrell A, Meng YH, Najy AJ, Hurst N Jr, Kim S, Kim CJ, Kim ES, Moon A, Kim EJ, Park SY, Kim HRC. An oncogenic activity of PDGF-C and its splice variant in human breast cancer. Growth Factors. 2019 Aug;37(3-4):131-145. PMID: 31542979
Najy AJ, Dyson G, Jena BP, Lin CY, Kim HR. Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis. Am J Physiol Cell Physiol. 2016 Feb 15;310(4):C293-304. PMID: 26157007
Huang W, Kim HR. Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis. J Biol Chem. 2015 Apr 3;290(14):9162-70. PMID: 25678707
Huang W, Fridman Y, Bonfil RD, Ustach CV, Conley-LaComb MK, Wiesner C, Saliganan A, Cher ML, Kim HR. A novel function for platelet-derived growth factor D: induction of osteoclastic differentiation for intraosseous tumor growth. Oncogene. 2012 Oct 18;31(42):4527-35. PMID: 22158043
Ustach CV, Huang W, Conley-LaComb MK, Lin CY, Che M, Abrams J, Kim HR. A novel signaling axis of matriptase/PDGF-D/ß-PDGFR in human prostate cancer. Cancer Res. 2010 Dec 1;70(23):9631-40. PMID: 21098708
Jung KK, Liu XW, Chirco R, Fridman R, Kim HR. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. EMBO J. 2006 Sep 6;25(17):3934-42. PMID: 16917503
